The proposed Reaction-Eikonal electromechanics model accurately reproduces cardiac physiological responses with significantly reduced computational time compared to the monodomain model.
May expedite in silico cardiac research; leaves open clinical validation before any practice impact.
We present a new model of human cardiac electromechanics for the left ventricle where electrophysiology is described by a Reaction–Eikonal model and which enables an off-line resolution of the reaction model, thus entailing a big saving of computational time. Subcellular dynamics is coupled with a model of tissue mechanics, which is in turn coupled with a Windkessel model for blood circulation. Our numerical results show that the proposed model is able to provide a physiological response to changes in certain variables (end-diastolic volume, total peripheral resistance, contractility). We also show that our model is able to reproduce with high accuracy and with a considerably lower computational time the results that we would obtain if the monodomain model should be used in place of the Eikonal model.
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Stella et al. (2022) studied this question.
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