Why the study?
Does dopamine at low dose range and high doses of insulin improve renal blood flow and myocardial contractility in dogs with acute ischaemic heart failure?
Does dopamine at low dose range and high doses of insulin improve renal blood flow and myocardial contractility in dogs with acute ischaemic heart failure?
In a canine model of acute ischemic heart failure, low-dose dopamine and high-dose insulin improved myocardial contractility and renal hemodynamics.
Should not alter human practice; leaves open translational studies of combined dopamine-insulin effects in acute heart failure.
The effects of acute ischaemic heart failure on renal blood flow and the influence of dopamine at low dose range and high doses of insulin were examined. Acute left ventricular (LV) failure was induced in dogs by injection of 50-micron plastic microspheres into the left main coronary artery. The dogs showed signs of severely depressed LV function. Cardiac output was decreased to a significantly greater extent than renal blood flow, and while total peripheral resistance was significantly increased, there were no significant changes in renal vascular resistance. The results indicate different sympathetic discharge to the various vascular beds during acute ischaemic heart failure. Dopamine at low dose range and high doses of insulin were found to improve myocardial contractility and to reduce renal vascular resistance and increase renal blood flow.
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Reikerås et al. (1986) studied this question.
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