Postoperative Inotrope and Vasopressor Use Following CABG: Outcome Data from the CAPS-Care Study
Why the study?
Does high hospital-level use of postoperative inotropes and vasopressors improve clinical outcomes in high-risk CABG patients?
Population
n=2390 high-risk elective or urgent CABG patients across 55 U.S. hospitals (CAPS-Care study, 2004-2005).
Comparison
High hospital-level use of postoperative… vs Medium or low hospital-level use of…
Design
Cohort
Follow-up
30-day
Authors
Discussion
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Member takes
Implication
High inotrope variation showed no CABG outcome association; leaves open whether selective use benefits highest-risk subgroups.
Structured PICO
Does high hospital-level use of postoperative inotropes and vasopressors improve clinical outcomes in high-risk CABG patients?
P
Population
n=2390 high-risk elective or urgent CABG patients across 55 U.S. hospitals (CAPS-Care study, 2004-2005).
I
Intervention
High hospital-level use of postoperative inotropes and vasopressors (highest tertile of use).
C
Comparator
Medium or low hospital-level use of postoperative inotropes and vasopressors (medium and low tertiles of use).
O
Outcome
Operative mortalityhard clinical
Considerable hospital-level variation in postoperative inotrope and vasopressor use following CABG does not appear to significantly impact risk-adjusted operative mortality or postoperative renal failure.
Limitations
- Observational design cannot establish causality or distinguish a superior pattern
- Lack of randomized prospective data
Cite This Study
Williams et al. (2011) studied this question.