Comparative Analysis of the Effects of Vasoperssin and Norepinephrine on the Renal Function in Patients Undergoing CABG; A Randomized Clinical Trial

Background: Coronary artery bypass grafting (CABG) is one the most common heart operations, in which blood vessels from other parts of the body, like the saphenous vein, are grafted to the blocked arteries. Due to the widespread use of vasoactive drugs in the course of surgery, and renal complications of these drugs, we aimed to determine the effect of norepinephrine on the renal function of patients with CABG, visiting the cardiac surgery ward of a university affiliated hospital in Ardabil, Iran, with the purpose of maintaining renal perfusion and preventing renal dysfunction in patients undergoing CABG. Objectives: This research aimed to determine and compare the effects of vasopressin and norepinephrine on the renal function of patients undergoing CABG. Methods: This study was a randomized clinical trial. A total of 120 candidates for CABG in a governmental hospital, Iran, during years 2016 - 2017, were randomly assigned into two groups. The patients' conditions across the two groups were compared regarding hemodynamics during surgery and post-surgical complications, e.g., renal function (Bun, Cr, and CLCr), using a researcher made questionnaire. Results: The results of our study showed that according to repeated measures test, there was no statistically significant difference during the intervention (P value > 0.05). However, the Independent t-test revealed a statistically significant difference between groups following CABG, which related to the clearance creatinine level. It indicated higher clearance creatinine level in the norepinephrine group (72.83 ± 25.03 and 78.16 ± 27.31) than the vasopressin group (64.33 ± 17.47 and 86.33 ± 30.54) (P < 0.05), however, the groups did not vary significantly from each other in other items. Conclusions: According to the results of the study, it could be stated that probable renal complications during operation can be reduced to some extent in patients undergoing CABG using inotrope and vasopressor drugs such as norepinephrine.