Why the study?
Does methoxamine improve left ventricular-arterial coupling in streptozotocin-diabetic rats?
Does methoxamine improve left ventricular-arterial coupling in streptozotocin-diabetic rats?
In a diabetic rat model, acute methoxamine administration improves ventricular and arterial contractile status but does not correct the optimality of energy transmission from the left ventricle to the arterial system.
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Methoxamine may augment elastance in diabetic rats without optimizing coupling; leaves open relevance to human diabetic cardiomyopathy.
Peng et al. (2000) studied this question.
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