Why the study?
Does levothyroxine replacement therapy improve brachial-ankle pulse wave velocity in female patients with subclinical hypothyroidism and autoimmune chronic thyroiditis?
Population
95 female patients with subclinical hypothyroidism and autoimmune chronic thyroiditis, compared with 42…
Comparison
Levothyroxine (l-T4) replacement therapy vs Placebo
Design
RCT, randomized, double-blind
Authors
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Supports levothyroxine to reduce arterial stiffness in subclinical hypothyroidism; extends RCT evidence for cardiovascular effects in autoimmune thyroiditis.
Does levothyroxine replacement therapy improve brachial-ankle pulse wave velocity in female patients with subclinical hypothyroidism and autoimmune chronic thyroiditis?
Levothyroxine replacement therapy significantly decreases arterial stiffness (measured by baPWV) in female patients with subclinical hypothyroidism and Hashimoto's disease, suggesting a potential cardiovascular protective effect.
Nagasaki et al. (2008) studied this question.
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