Why the study?
Does ropivacaine have a different placental transfer rate compared to bupivacaine in a human placental model?
Does ropivacaine have a different placental transfer rate compared to bupivacaine in a human placental model?
Ropivacaine and bupivacaine cross the human placenta at a similar rate, which is highly influenced by maternal and fetal protein concentration and fetal pH.
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Comparable transfer in this animal model should not guide clinical anesthetic choice; leaves open relative fetal exposure in human pregnancy.
Johnson et al. (1999) studied this question.
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