Why the study?
Does Angiotensin II administration cause resetting of the heart rate and sympathetic baroreflex in conscious rabbits?
Population
Conscious rabbits
Design
Preclinical
Follow-up
minutes to several days
Authors
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ANG II baroreflex resetting via area postrema in rabbits is hypothesis-generating; leaves open translation to human hypertension.
Does Angiotensin II administration cause resetting of the heart rate and sympathetic baroreflex in conscious rabbits?
Angiotensin II-dependent hypertension involves resetting of the HR and sympathetic baroreflexes, which requires an intact area postrema and can be partially prevented by alpha-1 adrenergic receptor antagonism.
Bishop et al. (1995) studied this question.