Why the study?
Does esmolol exert a direct negative inotropic effect on isolated cardiac muscle?
Population
Papillary muscles, trabeculae, and isolated myocytes excised from guinea pig and pig hearts
Design
Preclinical
Authors
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May explain esmolol's hemodynamic impact in vivo; leaves open translation to human myocardium and clinical use.
Does esmolol exert a direct negative inotropic effect on isolated cardiac muscle?
Esmolol exerts a direct negative inotropic effect on cardiac muscle by inhibiting the calcium current during the action potential.
Arlock et al. (2005) studied this question.
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