Why the study?
Does trans-Hexenoic Acid inhibit Coxsackievirus B3 and Enterovirus A71 replication in vitro?
Does trans-Hexenoic Acid inhibit Coxsackievirus B3 and Enterovirus A71 replication in vitro?
trans-Hexenoic Acid demonstrates in vitro antiviral activity against Coxsackievirus B3 and Enterovirus A71 by blocking viral entry.
) of 2.9 μM and 3.21 μM against CVB3 and EV-A71 infections, respectively. The time of addition assay revealed that THA inhibits both CVB3 and EV-A71 replication at the entry stage of infection. Additional results from this study further suggest that THA inhibits viral replication by blocking viral entry. Given that THA has received approval as a food additive, treatment of enterovirus infections with THA might be a safe therapeutic option or could pave the way for semisynthetic manufacturing of more antiviral drugs in the future.
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Olasunkanmi et al. (2023) studied this question.
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