March 1, 2000AJP Endocrinology and Metabolism

Hepatic α- and β-adrenergic receptors are not essential for the increase in Raduring exercise in diabetes

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Why the study?

Does direct hepatic adrenergic blockade reduce endogenous glucose production during exercise in poorly controlled alloxan-diabetic dogs?

Population

12 chronically catheterized and instrumented alloxan-diabetic dogs

Comparison

Alpha and beta adrenergic blockers infused in… vs Vehicle infusion in the portal vein

Design

Preclinical

Follow-up

150 minutes of exercise

Authors

RCRobert H. CokerMontana Technological University DLD. Borden LacyVanderbilt University PWPhillip E. WilliamsVanderbilt University

Discussion

Member takes

Implication

Direct hepatic adrenergic blockade does not blunt exercise-induced glucose production in diabetic dogs; leaves open its role in human diabetes.

Structured PICO

Does direct hepatic adrenergic blockade reduce endogenous glucose production during exercise in poorly controlled alloxan-diabetic dogs?

Population

12 chronically catheterized and instrumented alloxan-diabetic dogs

Intervention

Alpha (phentolamine) and beta (propranolol) adrenergic blockers infused in the portal vein

Comparator

Vehicle infusion in the portal vein

Outcome

Endogenous glucose production (R(a)) during 150-min moderate exercisesurrogate

Direct hepatic adrenergic stimulation does not play a role in the stimulation of endogenous glucose production during exercise in poorly controlled diabetes.

Cite This Study

Coker et al. (2000) studied this question.

synapsesocial.com/papers/6a83703c9492d09e1bb3fec6 https://doi.org/10.1152/ajpendo.2000.278.3.e444

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March 1, 2000AJP Endocrinology and Metabolism

Hepatic α- and β-adrenergic receptors are not essential for the increase in Raduring exercise in diabetes

View Full Paper

Ask AI

Bookmark

Why the study?

Does direct hepatic adrenergic blockade reduce endogenous glucose production during exercise in poorly controlled alloxan-diabetic dogs?

Population

12 chronically catheterized and instrumented alloxan-diabetic dogs

Comparison

Alpha and beta adrenergic blockers infused in… vs Vehicle infusion in the portal vein

Design

Preclinical

Follow-up

150 minutes of exercise

Authors

RCRobert H. CokerMontana Technological University DLD. Borden LacyVanderbilt University PWPhillip E. WilliamsVanderbilt University

Discussion

Member takes

Implication

Direct hepatic adrenergic blockade does not blunt exercise-induced glucose production in diabetic dogs; leaves open its role in human diabetes.

Structured PICO

Does direct hepatic adrenergic blockade reduce endogenous glucose production during exercise in poorly controlled alloxan-diabetic dogs?

Population

12 chronically catheterized and instrumented alloxan-diabetic dogs

Intervention

Alpha (phentolamine) and beta (propranolol) adrenergic blockers infused in the portal vein

Comparator

Vehicle infusion in the portal vein

Outcome

Endogenous glucose production (R(a)) during 150-min moderate exercisesurrogate

Direct hepatic adrenergic stimulation does not play a role in the stimulation of endogenous glucose production during exercise in poorly controlled diabetes.

Cite This Study

Coker et al. (2000) studied this question.

synapsesocial.com/papers/6a83703c9492d09e1bb3fec6 https://doi.org/10.1152/ajpendo.2000.278.3.e444

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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