What question did this study set out to answer?

To evaluate the impact of beta-adrenergic receptor blockade on lactate and glucose kinetics in exercising canines.

December 1, 1984Journal of Applied Physiology

Effect of beta-adrenergic blockade on lactate turnover in exercising dogs

View Full Paper

Ask AI

Bookmark

Authors

BIB. IssekutzDalhousie University

Discussion

Member takes

Overview

Experimental study reveals propranolol suppresses exercise-induced lactate production and increases blood glucose reliance in dogs, indicating hormonal control over muscle glycogenolysis.

Key Points

To evaluate the impact of beta-adrenergic receptor blockade on lactate and glucose kinetics in exercising canines.
Catheterized dogs ran on a treadmill at a 15% slope and 133 m/min under control conditions or during beta-adrenergic blockade.
Lactate and glucose turnover, along with the incorporation of plasma glucose into lactate, were quantified using primed constant-rate infusions of [U-14C]lactate, [3-3H]glucose, and [U-14C]glucose.
Propranolol was administered either as a pre-exercise intravenous bolus (250 µg/kg) or as a continuous primed infusion during steady-state exercise.
During steady-state running, continuous propranolol infusion reduced elevated lactate production back to near-resting levels.
Beta-adrenergic blockade doubled the exercise-induced increase in glucose production, glucose utilization, and metabolic clearance rate.
The proportion of lactate production derived from plasma glucose rose from 40–50% in untreated exercising dogs to 85–90% under beta-blockade.

Cite This Study

B. Issekutz (1984) studied this question.

synapsesocial.com/papers/6a930b299b844257c641a31c https://doi.org/10.1152/jappl.1984.57.6.1754

View Full Paper

Ask AI

Bookmark

December 1, 1984Journal of Applied Physiology

Effect of beta-adrenergic blockade on lactate turnover in exercising dogs

View Full Paper

Ask AI

Bookmark

Authors

BIB. IssekutzDalhousie University

Discussion

Member takes

Overview

Experimental study reveals propranolol suppresses exercise-induced lactate production and increases blood glucose reliance in dogs, indicating hormonal control over muscle glycogenolysis.

Key Points

To evaluate the impact of beta-adrenergic receptor blockade on lactate and glucose kinetics in exercising canines.
Catheterized dogs ran on a treadmill at a 15% slope and 133 m/min under control conditions or during beta-adrenergic blockade.
Lactate and glucose turnover, along with the incorporation of plasma glucose into lactate, were quantified using primed constant-rate infusions of [U-14C]lactate, [3-3H]glucose, and [U-14C]glucose.
Propranolol was administered either as a pre-exercise intravenous bolus (250 µg/kg) or as a continuous primed infusion during steady-state exercise.
During steady-state running, continuous propranolol infusion reduced elevated lactate production back to near-resting levels.
Beta-adrenergic blockade doubled the exercise-induced increase in glucose production, glucose utilization, and metabolic clearance rate.
The proportion of lactate production derived from plasma glucose rose from 40–50% in untreated exercising dogs to 85–90% under beta-blockade.

Cite This Study

B. Issekutz (1984) studied this question.

synapsesocial.com/papers/6a930b299b844257c641a31c https://doi.org/10.1152/jappl.1984.57.6.1754

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark