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December 1, 1984Journal of Autonomic Pharmacology

Effects of Propranolol and Exercise on Cardiac Dynamics and Organ Blood Flow Distribution in Dogs

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Why the study?

Does propranolol alter cardiac dynamics and organ blood flow distribution during rest and exercise in conscious dogs?

Population

Conscious dogs

Comparison

Propranolol administration followed by treadmill… vs Resting conditions and exercise without…

Design

Preclinical

Authors

LDLouis DumontUniversité de MontréalPMPaolo MagrassiHarvard UniversityRPR ParentInstitut National de Santé Publique du Québec

Discussion

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Overview

Should not change beta-blocker use in active patients; leaves open translation of canine perfusion effects to humans.

Key Points

  • To investigate the combined effects of beta-adrenoreceptor blockade via propranolol and physical exercise on cardiac performance and regional organ blood flow distribution in conscious dogs.
  • Assessed conscious dogs during treadmill exercise (8–10 km/h at 0% grade for 15 minutes) under control conditions and following propranolol administration.
  • Measured cardiac performance and regional blood perfusion across myocardial, skeletal muscle, splanchnic (liver and spleen), and other organ vascular beds at rest and during exercise.
  • Exercise alone increased cardiac performance and myocardial and muscular blood flow by >100%, while liver and spleen blood flow decreased by 30% and 34%, respectively.
  • Propranolol administration at rest significantly decreased blood flow to the liver (-50%) and spleen (-38%) with minimal hemodynamic changes elsewhere.
  • During exercise after propranolol, increases in cardiac performance and muscular blood flow were significantly restricted, and splanchnic perfusion showed no further reduction beyond resting post-drug levels.

Structured PICO

Does propranolol alter cardiac dynamics and organ blood flow distribution during rest and exercise in conscious dogs?

P
Population
Conscious dogs
I
Intervention
Propranolol administration followed by treadmill exercise (8-10 km/h and 0% grade for 15 min)
C
Comparator
Resting conditions (with and without propranolol) and exercise without propranolol
O
Outcome
Cardiac performance and peripheral blood flow distribution (myocardial, muscular, liver, spleen)surrogate

Propranolol significantly alters splanchnic blood flow at rest and limits the expected increases in cardiac performance and myocardial/muscular blood flow during exercise in dogs.

Cite This Study

Dumont et al. (1984) studied this question.

synapsesocial.com/papers/6a7dcd073fa445558d7d8910https://doi.org/10.1111/j.1474-8673.1984.tb00102.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1HEMODYNAMIC RESPONSE TO EXERCISE AFTER PROPRANOLOL IN NORMAL SUBJECTS1966 · 38 citations
  2. 2The peripheral vascular response to severe exercise in untethered dogs before and after complete heart block1971 · 67 citations
  3. 3CORONARY CIRCULATION DURING HEAVY EXERCISE IN CONTROL SUBJECTS AND PATIENTS WITH CORONARY HEART DISEASE1971 · 210 citations
  4. 4Blood flow to respiratory, cardiac, and limb muscles in dogs during graded exercise1976 · 100 citations
  5. 5Regional myocardial blood flow during graded treadmill exercise in the dog.1975 · 109 citations