What question did this study set out to answer?

December 1, 1986Clinical and Experimental Pharmacology and Physiology

Propranolol Ameliorates Exercise‐induced Regional Myocardial Dysfunction in Dogs

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Why the study?

Does propranolol ameliorate exercise-induced regional myocardial dysfunction in dogs with limited coronary reserve?

Population

Conscious, chronically instrumented dogs with limited coronary reserve induced by a hydraulic cuff occluder…

Design

Preclinical

Authors

NMN. MayerUniversity of Vienna GKGünther KrumplInternational Academy of Philosophy WSWolfgang SchneiderHumboldt-Universität zu Berlin

Discussion

Member takes

Implication

Supports demand reduction by propranolol in canine limited-reserve models; leaves open translation to human exercise-induced ischemia.

Key Points

To determine the effects of propranolol on exercise-induced regional myocardial dysfunction in an animal model with limited coronary reserve.
Limited coronary reserve was created in conscious, chronically instrumented dogs using a hydraulic cuff occluder on a coronary vessel.
Hemodynamic parameters and regional myocardial function were measured during treadmill exercise before and after intravenous administration of 0.5 mg/kg propranolol.
Coronary vessel occlusion preserved baseline resting myocardial function but caused severe regional dysfunction during treadmill exercise.
Propranolol significantly lowered heart rate, myocardial contractility, and systolic blood pressure, resulting in the amelioration of exercise-induced regional dysfunction.

Structured PICO

Does propranolol ameliorate exercise-induced regional myocardial dysfunction in dogs with limited coronary reserve?

Population

Conscious, chronically instrumented dogs with limited coronary reserve induced by a hydraulic cuff occluder placed on a coronary vessel

Intervention

Propranolol 0.5 mg/kg

Outcome

Exercise-induced regional myocardial dysfunctionsurrogate

Propranolol ameliorates exercise-induced regional myocardial dysfunction in a canine model of limited coronary reserve by reducing myocardial oxygen demand.

Cite This Study

Mayer et al. (1986) studied this question.

synapsesocial.com/papers/6a6f24793ce530166bc293b3 https://doi.org/10.1111/j.1440-1681.1986.tb02383.x

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Propranolol Ameliorates Exercise‐induced Regional Myocardial Dysfunction in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Propranolol Ameliorates Exercise‐induced Regional Myocardial Dysfunction in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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