April 11, 2008The Journal of PhysiologyOpen Access

Non‐selective β‐adrenergic blockade prevents reduction of the cerebral metabolic ratio during exhaustive exercise in humans

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Why the study?

Does propranolol prevent the reduction of the cerebral metabolic ratio during exhaustive exercise in males?

Population

8 males

Comparison

Administration of a non-selective… vs Exercise without propranolol (baseline/control)

Design

Other

Authors

TLThomas Seifert LarsenUniversity of Copenhagen PRPeter RasmussenGeneral Cardiology MOMorten OvergaardAarhus University

Discussion

Member takes

Overview

Supports beta2-receptor mediation of cerebral metabolic shifts during exercise; hypothesis-generating without current clinical implications.

Structured PICO

Does propranolol prevent the reduction of the cerebral metabolic ratio during exhaustive exercise in males?

Population

8 males

Intervention

Administration of a non-selective beta-adrenergic (beta1 + beta2) receptor antagonist (propranolol)

Comparator

Exercise without propranolol (baseline/control)

Outcome

Cerebral metabolic ratio of oxygen to carbohydrates [O(2)/(glucose + (1/2)lactate)]surrogate

Non-selective beta-blockade with propranolol prevents the exercise-induced reduction in the cerebral metabolic ratio, suggesting this reduction is mediated by a beta2-receptor mechanism.

Cite This Study

Larsen et al. (2008) studied this question.

synapsesocial.com/papers/6a7f25d832795c19ffb3a77f https://doi.org/10.1113/jphysiol.2008.151449

View Full Paper

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April 11, 2008The Journal of PhysiologyOpen Access

Non‐selective β‐adrenergic blockade prevents reduction of the cerebral metabolic ratio during exhaustive exercise in humans

View Full Paper

Ask AI

Bookmark

Why the study?

Does propranolol prevent the reduction of the cerebral metabolic ratio during exhaustive exercise in males?

Population

8 males

Comparison

Administration of a non-selective… vs Exercise without propranolol (baseline/control)

Design

Other

Authors

TLThomas Seifert LarsenUniversity of Copenhagen PRPeter RasmussenGeneral Cardiology MOMorten OvergaardAarhus University

Discussion

Member takes

Overview

Supports beta2-receptor mediation of cerebral metabolic shifts during exercise; hypothesis-generating without current clinical implications.

Structured PICO

Does propranolol prevent the reduction of the cerebral metabolic ratio during exhaustive exercise in males?

Population

8 males

Intervention

Administration of a non-selective beta-adrenergic (beta1 + beta2) receptor antagonist (propranolol)

Comparator

Exercise without propranolol (baseline/control)

Outcome

Cerebral metabolic ratio of oxygen to carbohydrates [O(2)/(glucose + (1/2)lactate)]surrogate

Non-selective beta-blockade with propranolol prevents the exercise-induced reduction in the cerebral metabolic ratio, suggesting this reduction is mediated by a beta2-receptor mechanism.

Cite This Study

Larsen et al. (2008) studied this question.

synapsesocial.com/papers/6a7f25d832795c19ffb3a77f https://doi.org/10.1113/jphysiol.2008.151449

Also Consider

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