July 16, 2009Journal of PerinatologyOpen Access

Rethinking IUGR in preeclampsia: dependent or independent of maternal hypertension?

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Why the study?

Does preeclampsia increase the risk of intrauterine growth restriction in pregnant women with and without chronic hypertension?

Population

998 pregnant women, including 430 cases with preeclampsia and 568 controls presenting for delivery at term…

Comparison

Preeclampsia (exposure) vs No preeclampsia

Design

Case-control

Authors

SSSindhu K. SrinivasSociety for Maternal-Fetal Medicine AEAndrea G. EdlowMassachusetts General Hospital PNP. NeffHospital of the University of Pennsylvania

Discussion

Member takes

Implication

Preeclampsia was associated with higher IUGR odds independent of chronic hypertension; supports disparate pathways yet leaves open need for prospective validation.

Structured PICO

Does preeclampsia increase the risk of intrauterine growth restriction in pregnant women with and without chronic hypertension?

Population

998 pregnant women, including 430 cases with preeclampsia (161 mild, 269 severe) and 568 controls presenting for delivery at term (≥37 weeks), at a single center in the United States.

Intervention

Preeclampsia (exposure)

Comparator

No preeclampsia (controls presenting for delivery at term)

Outcome

Prevalence of intrauterine growth restriction (IUGR) <10% and <5%hard clinical

Preeclampsia is independently associated with intrauterine growth restriction, but the lack of synergy with chronic hypertension suggests disparate mechanistic pathways for IUGR development.

Limitations

Mean gestational ages of cases and controls are different.
Potential for misclassification bias of exposure variables, particularly chronic hypertension.
Confounding by indication (mild cases may have been misclassified as severe if delivered before 37 weeks).
Assessment of exposure status may have been influenced by disease state.

Cite This Study

Srinivas et al. (2009) studied this question.

synapsesocial.com/papers/6a8370876abe336c4339c64e https://doi.org/10.1038/jp.2009.83

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Implication

Preeclampsia was associated with higher IUGR odds independent of chronic hypertension; supports disparate pathways yet leaves open need for prospective validation.

Rethinking IUGR in preeclampsia: dependent or independent of maternal hypertension?

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Rethinking IUGR in preeclampsia: dependent or independent of maternal hypertension?

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider