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August 27, 2015PLoS PathogensOpen Access

Twenty-Eight Years of Poliovirus Replication in an Immunodeficient Individual: Impact on the Global Polio Eradication Initiative

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Population

One white male from the UK with common variable immunodeficiency excreting type 2 vaccine-derived poliovirus…

Design

Case_report

Follow-up

28 years

Authors

GDGlynis DunnDKDimitra KlapsaTWThomas Wilton

Discussion

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Overview

Alerts to chronic VDPV excretion risk in immunodeficiency; leaves open whether stable vaccines are needed post-eradication.

Structured PICO

P
Population
One white male from the UK with common variable immunodeficiency (CVID) excreting type 2 vaccine-derived poliovirus for an estimated 28 years; additionally, 40 serum samples from healthy UK adults and Tg21-Bx transgenic mice expressing the human poliovirus receptor.

This case highlights the risk of chronic vaccine-derived poliovirus excretion in immunodeficient individuals and the potential need for new stable live-attenuated polio vaccines in the post-eradication era.

Cite This Study

Dunn et al. (2015) studied this question.

synapsesocial.com/papers/6a8377758df6316dcba9b8eahttps://doi.org/10.1371/journal.ppat.1005114
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transmissibility and Persistence of Oral Polio Vaccine Viruses: Implications for the Global Poliomyelitis Eradication Initiative1999 · 251 citations
  2. 2Transmission of Imported Vaccine‐Derived Poliovirus in an Undervaccinated Community in Minnesota2008 · 100 citations
  3. 3Multiple Independent Emergences of Type 2 Vaccine-Derived Polioviruses during a Large Outbreak in Northern Nigeria2013 · 160 citations
  4. 4Evolution and Circulation of Type-2 Vaccine-Derived Polioviruses in Nad Ali District of Southern Afghanistan during June 2009-February 20112014 · 11 citations
  5. 5Genetic recombination in wild-type poliovirus2002 · 61 citations