Why the study?
Systemic inflammatory response syndrome is a preventable cause of morbidity and mortality after ureteroscopy, but the individual roles of potential risk factors remain unclear.
Flexible ureteroscopy, ureteral access sheaths, postoperative stents, and positive urine cultures are significant risk factors for developing SIRS after ureteroscopy.
May warrant closer SIRS monitoring with flexible ureteroscopy, sheaths, or stents; leaves open causal confirmation in prospective trials.
Background: Systemic inflammatory response syndrome (SIRS) is a preventable cause of morbidity and mortality in patients undergoing ureteroscopy for urinary stone treatment. Multiple factors, including diabetes, hypertension, positive urine cultures, prophylactic antibiotics, and procedure duration, may influence SIRS risk, but their individual roles remain unclear. Methods: A descriptive, retrospective, and prospective cross-sectional study was conducted at Hospital General Dr. Manuel Gea González from January 2021 to December 2024. Inclusion criteria encompassed patients aged ≥18 years undergoing ureteroscopy. Data were collected on comorbidities, stone characteristics, procedural details, and outcomes. Statistical analyses were performed using logistic regression to identify risk factors. Ethical approval was obtained. Results: Among 351 patients, 60 (17.09%) developed SIRS. Factors associated with higher SIRS rates included flexible ureteroscopy (73.33%), ureteral access sheath use (50%), postoperative stents (60%), and preoperative positive urine cultures (33.33%). Patients with harder stones (≥1175 HU) experienced longer operative times (≥75 minutes). Conclusions: Flexible ureteroscopy, ureteral access sheaths, postoperative stents, and positive urine cultures are significant risk factors for SIRS.
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Venegas-Yañez et al. (2025) studied this question.
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