Why the study?
Does aspirin improve plasma markers of platelet activation and endothelial damage in ET patients with erythromelalgia?
Population
41 subjects total: 5 essential thrombocythemia patients suffering from erythromelalgia, 16 asymptomatic ET…
Comparison
Aspirin vs Asymptomatic ET patients and control subjects
Design
Cross-sectional
Authors
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Erythromelalgia in ET may involve aspirin-responsive platelet activation; hypothesis-generating and requires prospective validation before practice change.
Does aspirin improve plasma markers of platelet activation and endothelial damage in ET patients with erythromelalgia?
Erythromelalgia in essential thrombocythemia is driven by platelet activation and endothelial damage rather than thrombin generation, explaining its responsiveness to aspirin but not anticoagulants.
Genderen et al. (1996) studied this question.
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