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April 1, 1985Annals of Internal Medicine

Erythromelalgia Caused by Platelet-Mediated Arteriolar Inflammation and Thrombosis in Thrombocythemia

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Why the study?

Do cyclo-oxygenase inhibitors relieve pain and restore microvascular circulation in patients with erythromelalgia and thrombocythemia?

Population

40 patients with thrombocythemia in its primary form or associated with polycythemia vera, including 26 who…

Comparison

Cyclo-oxygenase inhibitors or busulfan vs Sodium-salicylate or platelet inhibitors

Design

Case_series

Authors

JMJan MichielsVlaams Instituut voor Biotechnologie

Discussion

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Implication

May relieve erythromelalgia symptoms in thrombocythemia; leaves open confirmation of cyclo-oxygenase inhibition and platelet mechanism in controlled trials.

Structured PICO

Do cyclo-oxygenase inhibitors relieve pain and restore microvascular circulation in patients with erythromelalgia and thrombocythemia?

P
Population
40 patients with thrombocythemia in its primary form or associated with polycythemia vera, including 26 who presented with erythromelalgia
I
Intervention
Cyclo-oxygenase inhibitors (aspirin and indomethacin) or busulfan
C
Comparator
Sodium-salicylate or platelet inhibitors (dipyridamole, sulfinpyrazone, ticlopidine, and dazoxiben)
O
Outcome
Relief of pain and restoration of microvascular circulation disturbances

Aspirin and indomethacin provide complete relief of erythromelalgia symptoms in patients with thrombocythemia, suggesting a platelet-mediated etiology.

Cite This Study

Jan Michiels (1985) studied this question.

synapsesocial.com/papers/6a8a41bb1c70e695d843573ahttps://doi.org/10.7326/0003-4819-102-4-466
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Essential Thrombocythaemia and Peripheral Gangrene1974 · 138 citations