November 1, 1989The Journal of Cell BiologyOpen Access

Intracellular and surface distribution of a membrane protein (CD8) derived from a single nucleus in multinucleated myotubes.

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Population

C2 mouse muscle cells (multinucleated myotubes)

Design

Preclinical

Authors

EREvelyn RalstonNational Institutes of Health ZHZach W. HallPennsylvania State University

Discussion

Member takes

Implication

Does not support changes in muscle gene therapy; leaves open nuclear domain effects in human cardiac myocytes.

Structured PICO

Population

C2 mouse muscle cells (multinucleated myotubes)

Intervention

Introduction of the gene encoding human T-lymphocyte antigen CD8 using a retroviral vector

Outcome

Intracellular and surface distribution of the CD8 protein

Widespread distribution of a surface membrane protein in multinucleated myotubes can result from localized synthesis and processing from a single nucleus.

Cite This Study

Ralston et al. (1989) studied this question.

synapsesocial.com/papers/6a837c2fc8eb9492e29ef1cb https://doi.org/10.1083/jcb.109.5.2345

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Intracellular and surface distribution of a membrane protein (CD8) derived from a single nucleus in multinucleated myotubes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Intracellular and surface distribution of a membrane protein (CD8) derived from a single nucleus in multinucleated myotubes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider