Sex Differences in Patients with Acute Decompensated Heart Failure in Japan: Observation from the KCHF Registry
Why the study?
The association between sex and long-term outcome in patients hospitalized for acute decompensated heart failure had not been fully studied in the Japanese population.
Does female sex reduce the risk of all-cause death or hospitalization for heart failure in patients with acute decompensated heart failure?
Population
3728 patients hospitalized for ADHF alive at discharge across 19 centres in Japan
Comparison
Women vs men
Design
Prospective multicentre cohort study
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
Female sex was associated with lower risk in acute decompensated HF; hypothesis-generating and requires prospective validation before influencing care.
Structured PICO
Does female sex reduce the risk of all-cause death or hospitalization for heart failure in patients with acute decompensated heart failure?
P
Population
3,728 patients hospitalized for acute decompensated heart failure (ADHF) who were alive at discharge, 44.8% women, median age 83 for women and 77 for men, from 19 centers in Japan.
I
Intervention
Female sex
C
Comparator
Male sex
O
Outcome
Composite of all-cause death or hospitalization for heart failure at 1 yearcomposite
In Japanese patients with acute decompensated heart failure, women have a lower adjusted risk of 1-year mortality or heart failure hospitalization compared to men, despite being older and having more preserved ejection fraction.
Cite This Study
Yamamoto et al. (2020) studied this question.