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January 1, 2004AJP Heart and Circulatory Physiology

Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury

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Why the study?

Does genetic overexpression of eNOS reduce myocardial infarct size and improve postischemic cardiac function in mice subjected to myocardial ischemia-reperfusion injury?

Population

Transgenic mice overexpressing the eNOS gene and non-transgenic mice subjected to 30 min of coronary artery…

Comparison

Genetic overexpression of eNOS vs Non-transgenic (NTG) mice

Design

Preclinical

Follow-up

Up to 7 days of reperfusion

Authors

SJSteven P. JonesJGJames J.M. GreerAKAman K. Kakkar

Discussion

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Overview

eNOS overexpression may limit infarct size in preclinical ischemia-reperfusion; leaves open functional recovery and clinical translation.

Structured PICO

Does genetic overexpression of eNOS reduce myocardial infarct size and improve postischemic cardiac function in mice subjected to myocardial ischemia-reperfusion injury?

P
Population
Transgenic mice overexpressing the eNOS gene (eNOS TG-Kobe and eNOS TG-RT strains) and non-transgenic (NTG) mice subjected to 30 min of coronary artery occlusion
I
Intervention
Genetic overexpression of eNOS (bovine eNOS in eNOS TG-Kobe strain, human eNOS in eNOS TG-RT strain)
C
Comparator
Non-transgenic (NTG) mice
O
Outcome
Myocardial infarct size at 24 hours of reperfusionsurrogate

Genetic overexpression of eNOS in mice attenuates myocardial infarct size after ischemia-reperfusion injury but does not significantly protect against postischemic myocardial contractile dysfunction.

Cite This Study

Jones et al. (2004) studied this question.

synapsesocial.com/papers/6a83822f48656d5c51fae583https://doi.org/10.1152/ajpheart.00129.2003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Attenuation of myocardial ischemia/reperfusion injury in mice with myocyte-specific overexpression of endothelial nitric oxide synthase2002 · 131 citations
  2. 2Endothelial NO Synthase Overexpression Inhibits Lesion Formation in Mouse Model of Vascular Remodeling2001 · 96 citations
  3. 3Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase.1998 · 280 citations
  4. 4Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice2002 · 268 citations
  5. 5Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice2002 · 313 citations