May 13, 2003Physiological Genomics

Exercise assessment of transgenic models of human cardiovascular disease

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Population

Genetically altered murine models of cardiovascular disease

Design

Review

Authors

DBDaniel BernsteinUniversity of Arkansas at Little Rock

Discussion

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Implication

Baseline phenotyping may miss murine cardiovascular phenotypes; leaves open optimal exercise protocols for translational research.

Structured PICO

Population

Genetically altered murine models of cardiovascular disease (including beta-adrenergic receptor knockouts, phospholamban knockout, dystrophin knockout, and mutant alpha-myosin heavy chain transgenic)

Intervention

Exercise testing methodologies (constant workload treadmill, incremental workload treadmill, swimming)

Outcome

Cardiovascular physiological phenotype unmaskingsurrogate

Exercise testing is essential for accurate physiological phenotyping of transgenic murine models of cardiovascular disease, as it can reveal abnormalities not present at rest.

Cite This Study

Daniel Bernstein (2003) studied this question.

synapsesocial.com/papers/6a83822f48656d5c51fae585 https://doi.org/10.1152/physiolgenomics.00188.2002

Topics

Sports cardiology

View Full Paper

Ask AI

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Exercise assessment of transgenic models of human cardiovascular disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Exercise assessment of transgenic models of human cardiovascular disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider