Key result
A 5-week treadmill exercise regimen revealed that transgenic mice overexpressing MLC2v had significantly decreased exercise capacity at high speeds compared with nontransgenic littermates.
Population
Transgenic mice overexpressing ventricular myosin regulatory light chain and nontransgenic littermates
Comparison
5-wk treadmill exercise regimen vs Nontransgenic littermates subjected to the same…
Design
Preclinical
Follow-up
5 weeks
Authors
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Treadmill protocols detect subtle phenotypes in transgenic models; extends preclinical phenotyping tools while leaving human translation open.
A 5-week treadmill exercise protocol successfully identifies subtle cardiovascular phenotypes, such as decreased exercise capacity and ultrastructural changes, in transgenic mice.
Fewell et al. (1997) studied Cardiovascular phenotypes. Treadmill exercise regimen vs. Nontransgenic (NTG) littermates was evaluated on Exercise capacity at relatively high treadmill speeds. A 5-week treadmill exercise regimen revealed that transgenic mice overexpressing MLC2v had significantly decreased exercise capacity at high speeds compared with nontransgenic littermates.
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