The Association of Nocardiosis and Pulmonary Alveolar Proteinosis

Case Studies1 February 1964The Association of Nocardiosis and Pulmonary Alveolar ProteinosisA Case StudyVINCENT T. ANDRIOLE, M.D., MAURICE BALLAS, M.D., GEORGE L. WILSON, M.D.VINCENT T. ANDRIOLE, M.D.Search for more papers by this author, MAURICE BALLAS, M.D.Search for more papers by this author, GEORGE L. WILSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-266 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPulmonary alveolar proteinosis was first described as a disease entity in 1958 by Rosen, Castleman, and Liebow (1). Forty-seven additional cases have been reported in detail (2-36, 36A, 36B) since their original report of 27 cases.Patients with alveolar proteinosis appear to have an increased susceptibility to pulmonary infections caused by a variety of organisms (1, 3, 15, 17, 18, 21-24, 27, 34, 37). Nevertheless, the frequent association of nocardiosis and pulmonary alveolar proteinosis (1, 15, 21, 27, 34), each a relatively uncommon disease, warrants further emphasis.This report concerns a patient with pulmonary alveolar proteinosis and nocardiosis with dissemination...References1. ROSENCASTLEMANLIEBOW SHBAA: Pulmonary alveolar proteinosis. New Eng. J. Med. 258: 1123, 1958. CrossrefMedlineGoogle Scholar2. SCHOENREINGOLDMEISTER IIML: Relapsing nodular, nonsuppurative panniculitis with lung involvement: clinical and autopsy findings with notes on pathogenesis. Ann. Intern. Med. 49: 687, 1958. LinkGoogle Scholar3. Case reports from Dearborn Veterans Administration, Livermore Veterans Administration: Quarterly Progress Report of the Veterans Administration—Armed Forces Study on Chemotherapy of Tuberculosis. 13: No. 3, pg. 25, October, 1958. Google Scholar4. LEVINSONJONESWINTROBECARTWRIGHT BRSMMGE: Thrombocythemia and pulmonary intra-alveolar coagulums in a young woman. Blood 13: 959, 1958. CrossrefMedlineGoogle Scholar5. FRIEDMANSTRICKLAND BCE: Pulmonary alveolar proteinosis: Clinico-Pathologic Conference. J. Tenn. Med. Ass. 51: 507, 1958. Google Scholar6. MOERTELWOOLNERBERNATZ CGLBPE: Pulmonary alveolar proteinosis. Proc. Mayo Clin. 34: 152, 1959. MedlineGoogle Scholar7. MCDOWELLWILLIAMSHINOS CSEJR: Pulmonary alveolar proteinosis: report of a case. Aust. Ann. Med. 8: 137, 1959. MedlineGoogle Scholar8. LULLBEYERMAIERMORSS GFJCJGDF: Pulmonary alveolar proteinosis: report of two cases. Amer. J. Roentgen. 82: 76, 1959. Google Scholar9. LANDISROSESTERNLIEB FBHDRO: Pulmonary alveolar proteinosis: case report with unusual clinical and laboratory manifestations. Amer. Rev. Resp. Dis. 80: 249, 1959. MedlineGoogle Scholar10. SIERACKIHORNKAY JCRCS: Pulmonary alveolar proteinosis: report of three cases. Ann. Intern. Med. 51: 728, 1959. LinkGoogle Scholar11. CARLSONMASON DJEW: Pulmonary alveolar proteinosis. Diagnosis of a probable case by examination of sputum. Amer. J. Clin. Path. 33: 48, 1960. CrossrefMedlineGoogle Scholar12. PITT LP: Pulmonary alveolar proteinosis: review of the literature and report of a case. J. Thorac. Surg. 39: 252, 1960. CrossrefGoogle Scholar13. FURSTBELLIRONS WEBMGV: Asymptomatic pulmonary alveolar proteinosis. Amer. J. Med. 28: 453, 1960. CrossrefMedlineGoogle Scholar14. HARRISONDIVERTIEOLSEN EGMBAM: Pulmonary alveolar proteinosis: report of a case with fatal outcome. JAMA 173: 327, 1960. CrossrefMedlineGoogle Scholar15. BURBANKMORRIONECUTLER BTGSS: Pulmonary alveolar proteinosis and nocardiosis. Amer. J. Med. 28: 1002, 1960. CrossrefMedlineGoogle Scholar16. PLENKSWIFTCHAMBERSPELTZER HPSAWLWE: Pulmonary alveolar proteinosis—a new disease? Radiology 74: 928, 1960. CrossrefMedlineGoogle Scholar17. HALL GF: Pulmonary alveolar proteinosis. Lancet 1: 1383, 1960. CrossrefMedlineGoogle Scholar18. WILLIAMSMEDLEYBROWN GEDRR: Pulmonary alveolar proteinosis. Lancet 1: 1385, 1960. CrossrefMedlineGoogle Scholar19. FRAIMOWCATHCARTTAYLOR WRTRC: Physiologic and clinical aspects of pulmonary alveolar proteinosis. Ann. Intern. Med. 52: 1177, 1960. LinkGoogle Scholar20. EDMONDSONGERE WRJB: Pulmonary alveolar proteinosis: case report. Ibid., p. 1310. Google Scholar21. ANDERSONECKLUNDKELLOW BRREWF: Pulmonary alveolar proteinosis with systemic nocardiosis. JAMA 174: 28, 1960. CrossrefMedlineGoogle Scholar22. JONES CC: Pulmonary alveolar proteinosis with unusual complicating infections. Report of two cases. Amer. J. Med. 29: 713, 1960. CrossrefMedlineGoogle Scholar23. TAXAYMONTGOMERYWILDISH EPRDDM: Studies of pulmonary alveolar microlithiasis and pulmonary alveolar proteinosis. Amer. J. Clin. Path. 34: 532, 1960. CrossrefMedlineGoogle Scholar24. BERGMANLINELL FF: Cryptococcosis as a cause of pulmonary alveolar proteinosis. Acta Path. Microbiol. Scand. 53: 217, 1961. CrossrefMedlineGoogle Scholar25. STERNBONDLAIOS HWFNC: Pulmonary alveolar proteinosis: a case report. Dis. Chest 34: 82, 1961. CrossrefGoogle Scholar26. SLUTZKERKNOLLELLISSILVERSTONE BHCFEIA: Pulmonary alveolar proteinosis: case report and review of literature. Arch. Intern. Med. (Chicago) 107: 264, 1961. CrossrefGoogle Scholar27. RAICHCASEYHALL RAFWH: Pulmonary and cutaneous nocardiosis. Amer. Rev. Resp. Dis. 83: 505, 1961. MedlineGoogle Scholar28. MANFREDIROSENBAUMBEHNKEWILLIAMS FDRHJF: Pulmonary alveolar proteinosis. Amer. J. Med. Sci. 242: 51, 1961. CrossrefMedlineGoogle Scholar29. AOKIOTANITOKUNAGAHIROTANISHIMURA SIMKH: A case report of pulmonary alveolar proteinosis. J. Jap. Soc. Intern. Med. 50: 471, 1961. CrossrefGoogle Scholar30. LOVETTEMAGOVERNKENT JBGJEM: Alveolar proteinosis. Arch. Intern. Med. (Chicago) 108: 611, 1961. CrossrefMedlineGoogle Scholar31. BRODSKYMAYOCK IRL: Pulmonary alveolar proteinosis: remission after therapy with trypsin and chymotrypsin. New Eng. J. Med. 265: 935, 1961. CrossrefMedlineGoogle Scholar32. MENDENHALLSOLUEASOM ESHF: Pulmonary alveolar proteinosis. Amer. Rev. Resp. Dis. 84: 876, 1961. MedlineGoogle Scholar33. DEPIERREABELANETGANTERCHOMETTEDELARUE RRPGJ: Proteinose alveolaire pulmonaire. J. Franc. Med. Chir. Thorac. 16: 447, 1962. MedlineGoogle Scholar34. SALTZMANCHICKCONANT HAEWNF: Nocardiosis as a complication of other diseases. Lab. Invest. 2: Part II, 1110, 1962. Google Scholar35. RAMIREZNYKAMCLAUGHLIN RJWJ: Pulmonary alveolar proteinosis: diagnostic techniques and observations. New Eng. J. Med. 268: 165, 1963. CrossrefMedlineGoogle Scholar36. KROEKERKROFMACHER EJS: Pulmonary alveolar proteinosis: report of a case with application of a special sputum examination as an aid to diagnosis. Amer. Rev. Resp. Dis. 87: 416, 1963. CrossrefMedlineGoogle Scholar36A. MAHAFFEYRUSHALLEN DEENJD: Pulmonary alveolar proteinosis: treatment with Varidase. J. Kentucky Med. Ass. 57: 1230, 1959. MedlineGoogle Scholar36B. SANDERSKAHANSBAR MMS: Pulmonary alveolar proteinosis: a review of the literature and report of two cases. Dis. Chest 42: 437, 1962. CrossrefMedlineGoogle Scholar37. ROSEN SH: Scientific exhibit. US Armed Forces Med. J. 11: 1507, 1960. MedlineGoogle Scholar38. DICKYUDELLRYANKUTZERDELMONICOPRIORCONNELL HJJWJMJEPAA: Pneumocystis carnii infection in New York State. Preliminary report. Proc. NY Ass. Pub. Health Lab. 37: 3, 1957. Google Scholar39. PAYSEURKONWALERHYDE CRBEL: Pulmonary alveolar proteinosis: progressive diffuse, fatal pulmonary disease. Amer. Rev. Tuber. 78: 906, 1958. MedlineGoogle Scholar40. CARABASIBARTA RJLL: Atypical pneumonitis with interstitial fibrosis: Unusual case receiving prolonged corticosteroid therapy: pulmonary alveolar proteinosis. Dis. Chest 36: 209, 1959. CrossrefMedlineGoogle Scholar41. FRAIMOWCATHCARTKRISHNERTAYLOR WRTJJRC: Pulmonary alveolar proteinosis. Correlation of pathological physiological findings in patient followed up with serial biopsies of lung. Amer. J. Med. 28: 458, 1960. CrossrefMedlineGoogle Scholar42. BIANCOTOMATIS SL: Proteinosi alveolare polmonare. Pathologica 52: 85, 1960. MedlineGoogle Scholar43. SNIDERWILNERLEWIS THFMBM: Cardiopulmonary physiology in a case of pulmonary alveolar proteinosis (abstract). Clin. Res. 6: No. 4, 1958. Google Scholar44. CROSSBINFORD RMCH: Is nocardia asteroides an opportunist? Lab. Invest. 11: Part 2, 1103, 1962. MedlineGoogle Scholar45. ANDRIOLE VT: Unpublished observations. Google Scholar46. MURRAYFINEGOLDFROMANWILL JFSMSDD: The changing spectrum of nocardiosis. Amer. Rev. Resp. Dis. 83: 315, 1961. MedlineGoogle Scholar47. LARSENDIAMONDCOLLINS MCHDHS: Nocardia asteroides infection: a report of seven cases. Arch. Intern. Med. (Chicago) 103: 712, 1959. CrossrefGoogle Scholar48. CUPPEDWARDSCLEVE CMWMEA: Nocardiosis of the central nervous system: report of two fatal cases. Ann. Intern. Med. 52: 223, 1960. LinkGoogle Scholar49. WHITMOREGRESHAMGRAYSON DNGAMJ: Nocardiosis in analinic patients given steroids. J. Clin. Path. 14: 259, 1961. CrossrefMedlineGoogle Scholar50. WELSHRHOADESJAQUES JDERW: Disseminated nocardiosis involving spinal cord. Arch. Intern. Med. 108: 73, 1961. CrossrefMedlineGoogle Scholar51. SPICKARDBUTLERANDRIOLEUTZ AWTVTJP: The improved prognosis of cryptococcal meningitis with amphotericin B therapy. Ann. Intern. Med. 58: 66, 1963. LinkGoogle Scholar52. HUTTERCOLLINS RVHS: The occurrence of opportunistic fungus infections in a cancer hospital. Lab. Invest. 11: Part 2, 1035, 1962. MedlineGoogle Scholar53. BRYANREADZIMMERMAN GTCHGR: Disseminated mucormycosis in a child with diabetes mellitus. J. Iowa Med. Soc. 48: 193, 1958. MedlineGoogle Scholar54. GABRIELE OF: Mucormycosis. Amer. J. Roentgen. 83: 227, 1960. Google Scholar55. WASSERMANSHIELSSPORN AJWSIN: Cerebral mucormycosis. Southern Med. J. 54: 403, 1961. CrossrefMedlineGoogle Scholar56. HOAGLANDSUBEBISHOPHOLDING RJJRHBF: Mucormycosis. Amer. J. Med. Sci. 242: 415, 1961. CrossrefMedlineGoogle Scholar57. BALLENGERGOLDRING CND: Nocardiosis in childhood. J. Pediat. 50: 145, 1957. CrossrefMedlineGoogle Scholar58. KRUEGERNORSAKENNEYPRICE EGLMA: Nocardiosis of the central nervous system. J. Neurosurg. 11: 226, 1954. CrossrefMedlineGoogle Scholar59. LISTWILLIAMSBEEMANPAYNE CFJRCBCA: Nocardiosis with multilocular cerebellar abscess. Ibid., p. 394. Google Scholar60. MUNSLOW RA: Actinomycotic (Nocardia asteroides) brain abscess with recovery. Ibid., p. 399. Google Scholar61. JACOBSONCLOWARD JRRB: Actinomycosis of the central nervous system (Nocardia asteroides). JAMA 137: 769, 1948. CrossrefMedlineGoogle Scholar62. BENBOWSMITHGRIMSON EPDTKS: Sulfonamide therapy in actinomycosis. Amer. Rev. Tuberc. 49: 395, 1944. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: VINCENT T. ANDRIOLE, M.D.; MAURICE BALLAS, M.D.; GEORGE L. WILSON, M.D.Affiliations: New Haven, ConnecticutFrom the Departments of Medicine, Pathology, and Surgery, Yale University School of Medicine, New Haven, Connecticut.This study was aided by grant FR 38-03, Clinical Research Center, United States Public Health Service, Bethesda, Maryland.Requests for reprints should be addressed to Vincent T. Andriole, M.D., Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven 11, Connecticut. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDetection of Anticytokine Autoantibodies and Clinical ApplicationsPulmonary alveolar proteinosis: time to shift?Anticytokine Autoantibody–Associated ImmunodeficiencyAutoantibody-Mediated Phenocopies of Primary Immunodeficiency DiseasesAnticytokine autoantibodies in infectious diseases: pathogenesis and mechanismsAutoimmune Pulmonary Alveolar ProteinosisPulmonary Alveolar ProteinosisDiseases Caused by Nocardia SpeciesPulmonary Alveolar ProteinosisPulmonary Alveolar ProteinosisDiffuse Interstitial Pulmonary FibrosisPrimary cerebellar nocardiosis and alveolar proteinosisNocardial Brain AbscessNocardial Brain AbscessThe medically important aerobic actinomycetes: epidemiology and microbiologyNocardia species: host-parasite relationshipsMycobacteriosis and Nocardiosis in the Immunocompromised HostNocardiaL-dopa-responsive movement disorder caused by Nocardia asteroides localized in the brains of miceThe Histopathology of Pulmonary Reactions to DrugsLung Response to Particulates with Emphasis on Asbestos and other Fibrous DustsUpdate on the Clinical Diagnosis, Management, and Pathogenesis of Pulmonary Alveolar Proteinosis (Phospholipidosis)Case 19-1983Fungal infections in the compromised hostPulmonary alveolar proteinosisDefective Lung Macrophages in Pulmonary Alveolar ProteinosisDAVID W. GOLDE, M.D., F.A.C.P., MARY TERRITO, M.D., THEODORE N. FINLEY, M.D., MARTIN J. CLINE, M.D., F.A.C.P.Nocardia asteroides and Nocardia brasiliensis infections in miceUnsuspected Pulmonary Alveolar Proteinosis Complicating Acute Myelogenous LeukemiaDisseminated nocardiosis presenting as testicular abscessTraitement d'une nocardiose pulmonaire par le co-trimoxazole. Etude clinique et microbiologiqueSekundäre maligne Tumoren der Bronchien und LungenMucormycosis-Changing StatusPulmonary alveolar proteinosis and pulmonary cryptococcosis in an adolescent boyNocardia asteroides infection complicating neoplastic diseaseSuccessful treatment of Pneumocystis carinii and Nocardia asteroides in a renal transplant patientNocardiosisNocardiosisNOCARDIA INFECTIONS IN A GENERAL HOSPITALNocardiosis: A reviewOpportunistic infections of the lungsNocardiosisPneumonia Due to Nocardia SpeciesDisorders of Pulmonary Surfactant HomeostasisNocardioseNocardiosePulmonary alveolar proteinosisDeep-Seated Mycotic Infections, Allergy to Fungi and MycotoxinsPurulent Constrictive Pericarditis Caused by Nocardia asteroidesGEORGE P. SUSENS, M.D., ABDUL AL-SHAMMA, M.D., JOHN C. ROWE, M.D., CHARLES C. HERBERT, M.D., MILTON L. BASSIS, M.D., GRANVILLE C. COGGS, M.D.Beitrag zur Alveolarproteinose der LungenNecrotizing Nocardial PneumonitisHAROLD C. NEU, M.D., MARGARITA SILVA, PH.D., ELIZABETH HAZEN, PH.D., SIDNEY H. ROSENHEIM, M.D.Pulmonary Alveolar Proteinosis Endobronchial TreatmentJOSE RAMIREZ-R., M.D., GUY D. CAMPBELL, M.D., F.A.C.P.Pulmonary Alveolar Proteinosis Report of Six Cases, Review of the Literature, and Formulation of a New TheoryROGER K. LARSON, M.D., F.A.C.P., RICHARD GORDINIER, M.D.Pulmonary Alveolar Proteinosis A Case with Improvement After a Short Course of Endobronchial Instillations of HeparinJOHN JEFFREY NICHOLAS, M.D., J. HOWLAND AUCHINCLOSS JR., M.D., LIONEL RUDOLPH, M.D.Nocardiosis During Steroid Treatment of Auto-immune Haemolytic Anaemia 1 February 1964Volume 60, Issue 2_Part_1Page: 266-275KeywordsMedical servicesNocardiosisProteinsPulmonary diseasesSurgery ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...