The study cloned and characterized ATP1AL1, proposing it as a new separate group within the family of human potassium-dependent ion pumps.
No immediate clinical implications; extends the potassium-dependent ATPase family but leaves functional roles open for validation.
The cDNA for ATP1AL1--the fifth member of the human Na,K-/H,K-ATPase gene family--was cloned and sequenced. The deduced primary ATP1AL1 translation product is 1,039 amino acids in length and has Mr of 114,543. The encoded protein has all of the structural features common to known catalytic subunits of P-type membrane ion-transporting ATPases and is equally distant (63-64% of identity) from the Na,K-ATPase isoforms and the gastric H,K-ATPase. The ATP1AL1 encoded protein was proposed to represent a new separate group within the family of human potassium-dependent ion pumps.
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Av et al. (1994) studied this question.
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