Why the study?
Does enalapril reduce proteinuria and improve clinical response in dogs with idiopathic glomerulonephritis?
Population
29 adult dogs with naturally occurring, idiopathic glomerulonephritis
Comparison
Enalapril for 6 months, added to low-dose… vs Placebo for 6 months, added to low-dose aspirin…
Design
Preclinical, randomly assigned, blinded
Follow-up
6 months
Authors
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Enalapril may reduce proteinuria in dogs with glomerulonephritis; leaves open confirmation in larger trials before routine use.
Does enalapril reduce proteinuria and improve clinical response in dogs with idiopathic glomerulonephritis?
Enalapril significantly reduces proteinuria and systolic blood pressure, improving clinical response in dogs with naturally occurring idiopathic glomerulonephritis.
Grauer et al. (2000) studied this question.
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