Why the study?
Does a single intravenous dose of doxycycline plus tinidazole prevent post-operative infectious problems in patients undergoing elective colorectal surgery?
Does a single intravenous dose of doxycycline plus tinidazole prevent post-operative infectious problems in patients undergoing elective colorectal surgery?
A single pre-operative dose of intravenous doxycycline and tinidazole is associated with a low rate of infectious complications in elective colorectal surgery.
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Associated with low infection rates in elective colorectal surgery; hypothesis-generating, requires RCTs before changing prophylaxis practice.
A prospective, multi-centre study was carried out in 572 patients undergoing colorectal surgery to investigate the effectiveness of a standardized antibiotic regimen as prophylaxis against post-operative infectious problems. Surgical departments used a single intravenous dose of 400 mg doxycycline plus 1600 mg tinidazole given 1-hour pre-operatively or at induction of anaesthesia. Patients were evaluated clinically 3, 7 and 15 days after surgery. Analysis of the results showed that 18 (3.1%) developed surgical infectious complications. Only 3 (0.5%) of the 21 patients who died during the hospital stay or observation period did so because of septic complications. No serious side-effects were seen. Overall compliance rate with the regimen was 96.9%. There were no signs of declining antibiotic efficacy in hospitals which had been using this regimen for up to 10 years.
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Steinar Danielsen (1988) studied this question.
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