Key result
Among 965 patients undergoing high-risk abdominal surgery, the overall rate of surgical infectious complications was 2.1% at up to 15 days post-surgery.
Why the study?
Does prophylactic intravenous doxycycline and tinidazole reduce post-operative infectious complications in patients undergoing elective non-colorectal abdominal surgery?
Cohort (n=965)
Yes
Does prophylactic intravenous doxycycline and tinidazole reduce post-operative infectious complications in patients undergoing elective non-colorectal abdominal surgery?
A standardized prophylactic regimen of intravenous doxycycline and tinidazole was associated with a low overall rate of infectious complications in elective non-colorectal abdominal surgery.
May support prophylaxis in high-risk abdominal surgery; leaves open comparative efficacy without randomized confirmation.
The incidence of post-operative infectious complications after high-risk biliary and gastroduodenal and all cases of small bowel surgery was investigated in 965 patients included in a prospective multi-centre study. Selected types of operation where antibiotic prophylaxis was considered beneficial were defined and patients in these categories were to receive a standardized prophylactic regimen of 400 mg doxycycline plus 1600 mg tinidazole intravenously 1-hour pre-operatively or at induction of anaesthesia. Of the 965 patients, 408 did not receive prophylaxis, 547 received the standard regimen and 10 were given a different prophylaxis. The overall compliance rate with the protocol was 89%. Analysis of the results of clinical evaluation of the patients 3, 7 and 15 days after surgery showed that only 21 (2.1%) of the 965 patients had developed surgical infectious complications. Two (0.2%) patients died of septic complications. No serious side-effects of the prophylactic regimen were recorded.
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Steinar Danielsen (1988) conducted a cohort in High-risk biliary, gastroduodenal, and small bowel surgery (n=965). Standardized antibiotic prophylaxis (doxycycline plus tinidazole) vs. No prophylaxis was evaluated on Surgical infectious complications. Among 965 patients undergoing high-risk abdominal surgery, the overall rate of surgical infectious complications was 2.1% at up to 15 days post-surgery.
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