Why the study?
Does a preoperative schedule of mechanical cleansing, formula diet, and doxycycline reduce postoperative sepsis in patients undergoing elective colorectal surgery?
Does a preoperative schedule of mechanical cleansing, formula diet, and doxycycline reduce postoperative sepsis in patients undergoing elective colorectal surgery?
A preoperative regimen of mechanical cleansing, formula diet, and doxycycline resulted in a low rate of septic complications (5.1%) in elective colorectal surgery.
Supports consideration of this regimen for sepsis prevention in elective colorectal surgery; leaves open efficacy versus controls in randomized trials.
A preoperative schedule based on three principles: rigorous mechanical cleansing of the intestine, nutrition for four days with a formula diet (Biosorbin MCT), and short-time systemic prophylaxis with doxycycline has been tested in a prospective study of 252 patients who underwent elective colorectal surgery. There were 11 wound infections, most of them of minor importance (4.4 per cent). Intra-abdominal abscesses occurred in two patients, both successfully reoperated, giving an overall incidence of septic complications of 5.1 per cent. The schedule was easy for the staff to administer, well tolerated by the patients, an inexpensive. The complication rate is probably as low as could be anticipated with this type of surgery.
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Rietz et al. (1984) studied this question.
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