Why the study?
Does doxorubicin treatment impair left ventricular diastolic function in patients with primary lung cancer?
Does doxorubicin treatment impair left ventricular diastolic function in patients with primary lung cancer?
Doxorubicin treatment in lung cancer patients causes early impairment of left ventricular diastolic function detectable by Doppler echocardiography before systolic changes occur.
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May warrant diastolic monitoring during doxorubicin in lung cancer; hypothesis-generating for early cardiotoxicity detection.
Eighteen patients were examined by Doppler echocardiography before and after treatment with doxorubicin (DXR). Early left ventricular filling rate decreased from 66 +/- 15 to 51 +/- 10 cm/sec whereas late filling rate increased from 48 +/- 12 to 61 +/- 9 cm/sec (p less than 0.05) with inversion of the E/A ratio suggesting an impairment of left ventricular diastolic function; conversely no significant changes were found in systolic function indexes. These results suggest that follow-up of patients treated with DXR must include left ventricular diastolic function studies. Doppler echocardiography can be successfully used to detect the presence of diastolic abnormalities.
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Maione et al. (1988) studied this question.
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