The Response of Hypercalcemia in Sarcoidosis to Chloroquine

Case Studies1 October 1963The Response of Hypercalcemia in Sarcoidosis to ChloroquineBARBARA J. HUNT, M.B., CH.B., EDMUND REINHOLD YENDT, M.D., F.R.C.P.BARBARA J. HUNT, M.B., CH.B., EDMUND REINHOLD YENDT, M.D., F.R.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-4-554 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypercalcemia occurs in sarcoidosis in 10 to 30 per cent of the cases (1-3). Its recognition and treatment are important because, if uncontrolled, it may lead to nephrocalcinosis, renal lithiasis, and irreversible renal failure (4, 5). The effects of the hypercalcemia per se also require prompt, effective treatment, as symptoms such as nocturia, frequency, persistent nausea and vomiting, muscular weakness and irritability, may cause more incapacity and distress to the patient than the sarcoid process itself.For the last 10 years, cortisone has been the treatment of choice in the hypercalcemia of sarcoidosis (4, 6-8). Its administration rapidly restores calcium...References1. HARRELLFISHER GTS: Blood chemical changes in Boeck's sarcoid with particular reference to protein, calcium and phosphatase values. J. Clin. Invest. 18: 687, 1939. CrossrefMedlineGoogle Scholar2. JACKSONDANCASTOR WPC: A consideration of the hypercalciuria in sarcoidosis, idiopathic hypercalciuria, and that produced by vitamin D; a new suggestion regarding calcium metabolism. J. Clin. Endocr. 19: 658, 1959. CrossrefGoogle Scholar3. MATHER G: Calcium metabolism and bone changes in sarcoidosis. Brit. Med. J. 1: 248, 1957. 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HUNT, M.B., CH.B.; EDMUND REINHOLD YENDT, M.D., F.R.C.P.Affiliations: Toronto,From the Department of Medicine, University of Toronto and the Farquharson Investigation Unit, Toronto General Hospital.This work was supported by grants from the Medical Research Council of Canada.Requests for reprints should be addressed to Edmund Reinhold Yendt, M.D., Department of Medicine, University of Toronto, 100 College Street, Toronto 5, Ontario, Canada. 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HENDRIX, M.D.Drugs in DermatologySarcoidosis 1 October 1963Volume 59, Issue 4 Page: 554-564 Keywords Calcium Hospital medicine Hypercalcemia Magnesium Muscular weakness Nausea Pathogenesis Renal failure Sarcoidosis Vomiting ePublished: 1 December 2008 Issue Published: 1 October 1963 PDF downloadLoading ...