What question did this study set out to answer?

To evaluate whether macrophage activation induced by chronic infection or adjuvants enhances host cell killing of intracellular Toxoplasma gondii.

November 1, 1972Infection and ImmunityOpen Access

A Role for Activated Macrophages in Resistance to Infection with Toxoplasma

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Authors

JRJack S. RemingtonBoston University JKJames L. KrahenbuhlLouisiana State University JMJoy W. MendenhallPalo Alto Veterans Institute for Research

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Implication

Experimental study demonstrates enhanced killing of intracellular Toxoplasma by activated murine macrophages, indicating a vital mechanism of host resistance against parasitic infection.

Key Points

To evaluate whether macrophage activation induced by chronic infection or adjuvants enhances host cell killing of intracellular Toxoplasma gondii.
Harvested macrophages from mice chronically infected with Toxoplasma gondii or Besnoitia jellisoni, or treated with Freund complete adjuvant.
Assessed intracellular Toxoplasma proliferation and host cell destruction using isotopically labeled uridine incorporation and monolayer plaque formation assays.
Activated macrophages exhibited an enhanced capacity to kill intracellular Toxoplasma compared to non-activated controls.
Parasite destruction in activated macrophages was evidenced by decreased incorporation of isotopically labeled uridine.
Activated macrophages inhibited intracellular Toxoplasma proliferation, preventing host macrophage destruction and subsequent invasion into fibroblast monolayers.

Cite This Study

Remington et al. (1972) studied this question.

synapsesocial.com/papers/6a838709cfeb7a169036acd3 https://doi.org/10.1128/iai.6.5.829-834.1972

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Implication

Experimental study demonstrates enhanced killing of intracellular Toxoplasma by activated murine macrophages, indicating a vital mechanism of host resistance against parasitic infection.

A Role for Activated Macrophages in Resistance to Infection with Toxoplasma

Discussion

Member takes

Implication

Key Points

Cite This Study

A Role for Activated Macrophages in Resistance to Infection with Toxoplasma

Discussion

Member takes

Implication

Key Points

Cite This Study

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