This preclinical study demonstrates that electrical transmural stimulation induces a sympathetic, purinergic contractile response in the canine mesenteric artery.
Extends preclinical evidence for purinergic cotransmission; hypothesis-generating with no immediate clinical implications.
Electrical transmural stimulation of isolated mesenteric artery of the dog produced a transient contraction which consisted of adrenergic and non-adrenergic components. In contrast to the adrenergic component, the nonadrenergic component was resistant to prazosin and other adrenoceptor-blocking agents. However, the nonadrenergic component was completely blocked by guanethidine and by desensitization with alpha,beteta-methylene-ATP (alpha,beta-MeATP). Desensitization induced by alpha,beta-MeATP also inhibited the contractile response to ATP but not the adrenergic responses induced by electrical transmural stimulation and exogenous noradrenaline. These results suggest that the nonadrenergic contraction induced by electrical transmural stimulation is a sympathetic, purinergic response.
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A 1986 study studied this question.
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