Key result
Electrical transmural stimulation of isolated dog mesenteric artery produced a sympathetic purinergic response likely caused by a P2x-purinergic receptor-selective mechanism rather than ATP.
The sympathetic purinergic response in dog mesenteric arteries may be mediated by a P2x-purinergic receptor-selective mechanism or substance other than ATP.
Offers no immediate clinical implications; leaves open whether P2X-selective mechanisms mediate sympathetic responses in human vessels.
In the presence of prazosin and propranolol, electrical transmural stimulation of isolated dog mesenteric artery produced a sympathetic purinergic contraction, which was followed by a relaxation in PGF2 alpha-contracted arteries. Such purinergic responses were mimicked by brief exposure to alpha, beta-methylene ATP (alpha, beta-Me ATP) and were completely inhibited after desensitization of P2x-purinergic receptors. However, exogenous ATP predominantly evoked a relaxation in PGF2 alpha-contracted artery. These results suggest that the sympathetic purinergic response may be caused by a P2x-purinergic receptor-selective mechanism or substance, rather than ATP.
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Muramatsu et al. (1990) studied this question. Electrical transmural stimulation was evaluated on Sympathetic purinergic contraction and relaxation. Electrical transmural stimulation of isolated dog mesenteric artery produced a sympathetic purinergic response likely caused by a P2x-purinergic receptor-selective mechanism rather than ATP.
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