What question did this study set out to answer?

To evaluate autonomic reflex profiles in patients with essential hypertension before and after antihypertensive treatment compared with normotensive controls.

April 1, 1995Medical Journal of IndonesiaOpen Access

Isometric exercise, cold pressure test, and valsalva maneuver in subjects with essential hypertension and normal blood pressure

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Why the study?

Does autonomic reflex testing reveal differences in sympathetic and vagal activation between patients with essential hypertension and normotensive controls?

Population

14 subjects, comprising 8 patients with uncomplicated mild to moderate essential hypertension and 6…

Comparison

Autonomic reflex testing before and after blood… vs Normotensive control group undergoing the same…

Design

Case-control

Authors

PKPeter KaboHasanuddin University

Discussion

Member takes

Implication

Impaired vagal responses may precede essential hypertension; hypothesis-generating for autonomic testing and should not yet change practice.

Key Points

To evaluate autonomic reflex profiles in patients with essential hypertension before and after antihypertensive treatment compared with normotensive controls.
Evaluated cardiovascular responses to isometric exercise, cold pressor testing, and the Valsalva maneuver in 8 patients with uncomplicated mild-to-moderate essential hypertension (mean age 48 ± 2.7 years) and 6 age-matched normotensive controls (mean age 40 ± 2 years).
Measured percentage changes in heart rate and blood pressure at baseline and after blood pressure reduction achieved via diet or low-dose thiazide therapy in the hypertensive group.
Before treatment, the percentage increase in blood pressure during isometric exercise and cold pressor testing was attenuated in hypertensive patients compared with controls.
During the Valsalva maneuver, hypertensive patients showed a significantly smaller percentage increase in heart rate during phases II and III (p < 0.05) and a significantly smaller decrease in heart rate during phases I and IV (p < 0.05) relative to controls.
Following blood pressure lowering with diet or thiazides, differences in pressor responses and sympathetic heart rate increases normalized, but the impaired vagal heart rate deceleration during phases I and IV remained unchanged.

Structured PICO

Does autonomic reflex testing reveal differences in sympathetic and vagal activation between patients with essential hypertension and normotensive controls?

Population

14 subjects, comprising 8 patients with uncomplicated mild to moderate essential hypertension (mean age 48) and 6 age-matched normotensive controls (mean age 40).

Intervention

Autonomic reflex testing (isometric exercise, cold pressor test, and Valsalva maneuver) before and after blood pressure reduction via diet or low-dose thiazide.

Comparator

Normotensive control group undergoing the same autonomic reflex testing.

Outcome

Percentage changes in heart rate and blood pressure during autonomic reflex testing.surrogate

The persistence of impaired vagal responses during the Valsalva maneuver after blood pressure reduction suggests that vagal impairment may be a primary contributor to essential hypertension.

Cite This Study

Peter Kabo (1995) studied this question.

synapsesocial.com/papers/6a83883630ab63da3ee31071 https://doi.org/10.13181/mji.v4i2.902

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Implication

Impaired vagal responses may precede essential hypertension; hypothesis-generating for autonomic testing and should not yet change practice.

Isometric exercise, cold pressure test, and valsalva maneuver in subjects with essential hypertension and normal blood pressure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Isometric exercise, cold pressure test, and valsalva maneuver in subjects with essential hypertension and normal blood pressure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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