Why the study?
Does intra-arterial bretylium tosylate selectively block sympathetic noradrenergic fibers without affecting cholinergic fibers or responses to injected catecholamines in normotensive men?
Population
Male normotensive subjects
Comparison
Intra-arterial infusion of bretylium tosylate… vs Uninfused contralateral forearm/hand or…
Design
Other
Follow-up
Acute (up to 1.5 hours post-infusion)
Authors
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May aid selective autonomic research tools; leaves open clinical translation without randomized confirmation.
Does intra-arterial bretylium tosylate selectively block sympathetic noradrenergic fibers without affecting cholinergic fibers or responses to injected catecholamines in normotensive men?
Bretylium tosylate acts as a selective sympathetic noradrenergic blocking agent with initial direct sympathomimetic vasoconstrictor effects, without blocking cholinergic fibers or adrenoreceptors.
Blair et al. (1960) studied this question.
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