The effects of parathyroid hormone on L-type calcium channel currents in vascular smooth muscle and ventricular myocytes are mediated by a cAMP-dependent mechanism.
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cAMP mediation of PTH effects on L-type currents in animal cells requires human confirmation; leaves open clinical relevance.
The present study demonstrated that L channel currents were decreased in smooth muscle cells, and increased in ventricular myocytes by both bovine parathyroid hormone, (bPTH-(1-34)), and dibutyryl cyclic AMP (db-cAMP), using the whole cell version of the patch clamp technique with Ba2+ as the charge carrier. The effects of bPTH-(1-34) and db-cAMP on L channel currents were additive but not synergistic. Furthermore, the effects of bPTH-(1-34) on L channel currents in these 2 cell preparations were abolished in the presence of a cAMP antagonist. These results suggest that the effects of bPTH-(1-34) on L channel currents in vascular smooth muscle cells and ventricular myocytes are mediated by a cAMP-dependent mechanism.
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Wang et al. (1991) studied this question.
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