Why the study?
Factors associated with clopidogrel resistance may differ in patients with stroke recurrence receiving single versus dual antiplatelet treatment.
Does single antiplatelet therapy with clopidogrel compared to dual antiplatelet therapy affect the frequency of clopidogrel resistance in patients with recurrent ischemic stroke?
Population
275 recurrent ischemic stroke patients
Comparison
Clopidogrel SAPT vs aspirin and clopidogrel DAPT
Design
Comparative observational study
Authors
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May mitigate clopidogrel resistance in recurrent stroke, but this observational finding is hypothesis-generating.
Does single antiplatelet therapy with clopidogrel compared to dual antiplatelet therapy affect the frequency of clopidogrel resistance in patients with recurrent ischemic stroke?
In patients with recurrent ischemic stroke, clopidogrel resistance is more frequent with clopidogrel monotherapy than with dual antiplatelet therapy, and smoking appears to have a protective effect against resistance in the monotherapy group.
Kang et al. (2021) studied this question.
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