Key result
Dual antiplatelet resistance linked to ~50% incidence of silent cerebral infarction after coronary angiography.
Why the study?
Does insufficient platelet inhibition increase the risk of silent embolic cerebral infarctions after coronary angiography in patients scheduled for CABG?
Comparison
Insufficient platelet inhibition vs sufficient platelet inhibition measured by VerifyNow system
Design
Retrospective and prospective observational cohort studies
Authors
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May warrant caution in CABG candidates undergoing angiography; hypothesis-generating and requires prospective validation before guiding therapy.
Observational (n=374)
Does insufficient platelet inhibition increase the risk of silent embolic cerebral infarctions after coronary angiography in patients scheduled for CABG?
Absolute Event Rate: 50% vs 4%
p-value: p=0.023
Insufficient platelet inhibition, as measured by higher aspirin and P2Y12 reaction units, is associated with an increased risk of silent embolic cerebral infarctions following coronary angiography.
Kim et al. (2011) conducted an observational in Patients scheduled for coronary artery bypass surgery (n=374). Insufficient platelet inhibition (antiplatelet resistance) vs. Sufficient platelet inhibition (no resistance) was evaluated on Silent embolic cerebral infarction (SECI) (p=0.023). Resistance to antiplatelet agents was associated with increased incidence of silent embolic cerebral infarction after coronary angiography (50% for dual resistance vs 4% for no resistance; P=0.023).
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