Why the study?
Does dexrazoxane reduce doxorubicin-mediated cardiac damage in intact and ovariectomized young female rats at rest and after swim training?
Population
Female Sprague-Dawley rats, intact or ovariectomized at weaning, separated into sedentary and swim cohorts
Comparison
Dexrazoxane before doxorubicin or doxorubicin… vs PBS (phosphate-buffered saline)
Design
Preclinical
Authors
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Rat findings should not change practice; hypothesis-generating for dexrazoxane inefficacy and exercise effects on doxorubicin cardiotoxicity.
Does dexrazoxane reduce doxorubicin-mediated cardiac damage in intact and ovariectomized young female rats at rest and after swim training?
In a rat model, dexrazoxane failed to protect against doxorubicin-induced cardiotoxicity in young females, and exercise (swim training) exacerbated the cardiac damage.
Calvé et al. (2012) studied this question.
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