Why the study?
Does exercise training prevent doxorubicin-induced cardiotoxicity without compromising antitumor efficacy in a rat tumor model?
Population
Female Fisher 344 rats inoculated with 1×10(6) MatBIII tumor cells
Comparison
Wheel run exercise training combined with… vs Sedentary condition combined with doxorubicin or…
Design
Preclinical, randomly assigned
Follow-up
Up to 5 days following treatment
Authors
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Exercise preserves DOX antitumor efficacy while protecting cardiac function in rats; leaves open translation to human cancer patients.
Does exercise training prevent doxorubicin-induced cardiotoxicity without compromising antitumor efficacy in a rat tumor model?
Exercise training protects against doxorubicin-induced cardiac dysfunction without reducing its antitumor efficacy, potentially mediated by reduced cardiac doxorubicin accumulation.
Parry et al. (2015) studied this question.
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