Why the study?
Does concomitant low-intensity aerobic exercise and doxorubicin improve tumor inhibition and offset cardiotoxicity in a murine melanoma model?
Population
6- to 8-week-old male C57BL/6 mice injected subcutaneously with 3 × 10^5 B16F10 melanoma cells (n=48)
Comparison
Doxorubicin combined with exercise vs Sedentary + vehicle, Sedentary + doxorubicin…
Design
Preclinical, randomly divided into four cohorts
Follow-up
16 days
Authors
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May enhance doxorubicin antitumor efficacy without offsetting cardiotoxicity in murine models; leaves open clinical translation for anthracycline-treated patients.
Does concomitant low-intensity aerobic exercise and doxorubicin improve tumor inhibition and offset cardiotoxicity in a murine melanoma model?
Low-intensity aerobic exercise increases the efficacy of doxorubicin in inhibiting tumor growth but does not mitigate subclinical doxorubicin-induced cardiotoxicity in a murine melanoma model.
Sturgeon et al. (2014) studied this question.
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