Key result
Moderate aerobic exercise during early-life doxorubicin treatment significantly mitigated decreases in ejection fraction and fractional shortening in pediatric murine models.
Why the study?
Does moderate aerobic exercise during early-life doxorubicin exposure mitigate cardiotoxicity in pediatric murine models?
Population
Pediatric murine models of doxorubicin exposure, including non-tumor-bearing immune competent mice and…
Comparison
Moderate aerobic exercise for 2 weeks… vs Sedentary mice receiving doxorubicin treatment.
Design
Preclinical
Follow-up
2 weeks
Authors
Loading...
Exercise may mitigate doxorubicin cardiotoxicity in pediatric models; hypothesis-generating and requires prospective human trials.
Does moderate aerobic exercise during early-life doxorubicin exposure mitigate cardiotoxicity in pediatric murine models?
Moderate aerobic exercise during early-life doxorubicin exposure mitigates cardiotoxicity in murine models, highlighting the potential of concurrent exercise in cardio-oncology.
Wang et al. (2018) studied Doxorubicin-induced cardiotoxicity. Moderate aerobic exercise vs. Sedentary was evaluated on Ejection fraction and fractional shortening. Moderate aerobic exercise during early-life doxorubicin treatment significantly mitigated decreases in ejection fraction and fractional shortening in pediatric murine models.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: