January 21, 2025Journal of Translational MedicineOpen Access

Exercise training partly ameliorates cardiac dysfunction in mice during doxorubicin treatment of breast cancer

Q: What is the clinical evidence from this study?

Study design: Other. Population: Doxorubicin-induced cardiotoxicity in breast cancer (n=74). Intervention: Voluntary wheel-running exercise training vs. No exercise (locked wheels). Primary outcome: Left ventricle glucose uptake, ejection fraction, and left ventricle mass.

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Key result

In a murine breast cancer model, voluntary exercise training moderated doxorubicin-induced cardiotoxicities by blunting the increase in left ventricle glucose uptake, preventing left ventricle atrophy, and improving ejection fraction.

Why the study?

The effects of exercise training on cardiac function and glucose metabolism during doxorubicin treatment in breast cancer models remained unclear.

Does voluntary exercise training ameliorate doxorubicin-induced cardiotoxicity in a murine breast cancer model?

Population

Murine breast cancer model

Comparison

Exercise training vs no exercise training during doxorubicin treatment

Design

Animal study

Follow-up

After two and four DOX-doses

Authors

TUTytti‐Maria UurasmaaUniversity of Turku PBPauline BourdinUniversity of Turku WNWail NammasUniversity of Turku

Discussion

Member takes

Implication

Supports exercise to mitigate doxorubicin cardiotoxicity in murine models; hypothesis-generating for clinical translation.

Structured PICO

Does voluntary exercise training ameliorate doxorubicin-induced cardiotoxicity in a murine breast cancer model?

Population

74 ten-week-old female mice, including tumor-free and mammary tumor-bearing models treated with doxorubicin, followed for approximately 4 weeks.

Intervention

Voluntary exercise training (ET) during doxorubicin (DOX) treatment

Comparator

Unexercised DOX-treated mice, tumor-bearing mice without DOX, and tumor-free exercised mice

Outcome

Structural, functional, vascular, oxidative stress, and glucose uptake alterations of the left ventricle (LV)surrogate

Voluntary exercise training mitigates doxorubicin-induced cardiotoxicity, including LV atrophy and reduced ejection fraction, in a murine breast cancer model.

Limitations

Mouse running activities might be underestimated because the mice were housed in pairs.
The use of a non-orthotopic breast cancer model might yield different results from an orthotopic primary tumor model.
Different euthanasia times of the tumor-bearing mice may increase the variability of endpoint parameters and introduce survivor bias.
Voluntary exercise training amount cannot be controlled.

Cite This Study

Uurasmaa et al. (2025) studied Doxorubicin-induced cardiotoxicity in breast cancer (n=74). Voluntary wheel-running exercise training vs. No exercise (locked wheels) was evaluated on Left ventricle glucose uptake, ejection fraction, and left ventricle mass. In a murine breast cancer model, voluntary exercise training moderated doxorubicin-induced cardiotoxicities by blunting the increase in left ventricle glucose uptake, preventing left ventricle atrophy, and improving ejection fraction.

synapsesocial.com/papers/6a955cde7ee17f80122cb393 https://doi.org/10.1186/s12967-025-06108-y

Topics

Echocardiography

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Exercise training partly ameliorates cardiac dysfunction in mice during doxorubicin treatment of breast cancer

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Exercise training partly ameliorates cardiac dysfunction in mice during doxorubicin treatment of breast cancer

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

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Topics

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