Why the study?
It was uncertain whether clinical outcomes differ following RFC-ACS versus IFC-ACS and whether outcomes are affected by a specific inflammatory response.
Does culprit plaque morphology (intact vs. ruptured fibrous cap) determine inflammatory risk and clinical outcomes in patients with acute coronary syndrome?
Population
398 consecutive ACS patients
Comparison
RFC-ACS vs IFC-ACS
Design
Prospective translational cohort study
Follow-up
2 years
Authors
Loading...
Supports lower MACE+ with IFC-ACS; leaves open whether plaque morphology should guide risk stratification in ACS.
Does culprit plaque morphology (intact vs. ruptured fibrous cap) determine inflammatory risk and clinical outcomes in patients with acute coronary syndrome?
In patients with acute coronary syndrome, an intact fibrous cap culprit lesion is associated with a distinct, lower inflammatory response and a significantly lower 2-year risk of major adverse cardiovascular events compared to plaque rupture.
Gerhardt et al. (2023) studied this question.