January 1, 1998Endocrine Research
Molecular and cellular mechanism of angiotensin II-mediated apoptosis
Population
Cell lines including vascular smooth muscle cells, cardiomyocytes, neuronal cell and fibroblasts
Design
Preclinical
Authors
Discussion
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Member takes
Implication
AT2 signaling may offer a novel therapeutic target; leaves open translation to clinical cardiovascular applications.
Structured PICO
P
Population
Cell lines including vascular smooth muscle cells, cardiomyocytes, neuronal cell (PC12W) and fibroblasts (R3T3)
I
Intervention
Angiotensin II type 2 (AT2) receptor activation
O
Outcome
Molecular mechanisms of apoptosis and growth inhibition (activation of tyrosine phosphatases, inactivation of MAP kinase, Bcl-2 dephosphorylation, up-regulation of Bax)surrogate
The AT2 receptor counteracts AT1 receptor effects by promoting apoptosis and inhibiting growth through specific intracellular signaling pathways involving MKP-1 and ERK.
Cite This Study
Horiuchi et al. (1998) studied this question.