Angiotensin II type 2 receptor mediates programmed cell death.
Population
PC12W cells and R3T3 cells expressing abundant AT2 receptor but not AT1 receptor
Design
Preclinical
Authors
Discussion
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Member takes
Implication
AT2 receptor may drive fetal apoptosis; leaves open adult cardiovascular roles.
Structured PICO
P
Population
PC12W cells (rat pheochromocytoma cell line) and R3T3 cells (mouse fibroblast cell line) expressing abundant AT2 receptor but not AT1 receptor
I
Intervention
AT2 receptor activation and inhibition of MAP kinase phosphatase 1 (using vanadate or antisense oligonucleotide)
O
Outcome
Programmed cell death (apoptosis)surrogate
The study demonstrates that the angiotensin II type 2 receptor mediates apoptosis via MAP kinase dephosphorylation, suggesting a role in developmental biology and pathophysiology.
Cite This Study
Yamada et al. (1996) studied this question.