Why the study?
Does candesartan cilexetil prevent stroke, kidney dysfunction, and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats?
Population
Stroke-prone spontaneously hypertensive rats (SHRSP)
Comparison
Candesartan cilexetil or enalapril maleate via… vs Control SHRSP (untreated)
Design
Preclinical
Authors
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Low-dose candesartan may confer BP-independent stroke and renal protection in hypertensive rats; leaves open translation to human end-organ outcomes.
Does candesartan cilexetil prevent stroke, kidney dysfunction, and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats?
Candesartan cilexetil protects against end-organ damage in stroke-prone spontaneously hypertensive rats, with low doses providing protection independent of blood pressure reduction.
Inada et al. (1997) studied this question.
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